What is the role of Plasminogen Activator Inhibitor-1 (PAI-1) in fibrinolysis?

A It activates plasminogen to form plasmin
B It inhibits the activation of plasminogen to form plasmin ✓
C It has no effect on fibrinolysis
D It is a type of coagulation factor

Explanation

PAI-1 is a protein that inhibits the activation of plasminogen to form plasmin, thereby reducing fibrinolysis and increasing the risk of thrombosis.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high