A patient with a history of thrombosis is found to have a mutation in the MTHFR gene. What is the likely consequence of this mutation?

A Decreased production of homocysteine
B Increased production of homocysteine ✓
C Decreased activity of antithrombin III
D Increased activity of protein C

Explanation

A mutation in the MTHFR gene can lead to increased production of homocysteine, which is a prothrombotic amino acid that can increase the risk of thrombosis.

Source

New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high