Dobutamine Drug : Dose, Action, side effects and Contra-indications


Dobutamine is a beta-1 agonist used in the treatment of Heart failure, Hypotension, cardiac decompensation in patients with organic heart disease or from cardiac surgery.

Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with negligible effects on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine.

Dose of Dobutamine Drugs

  • 5-10 μg/kg/min. rate or peripheral vascular.

Action of Dobutamine

  • Dobutamine is a sympathomimetic agonist. It works by activating the receptors in the heart. This makes the heart pump blood with more strength and force and increases its pumping capacity in conditions such as heart failure.
  • It increases the cardiac output without increasing the heart release endogenous nor-actions.

Common side effects of Dobutamine

Contra-indications of Dobutamine

  • HOCM

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