A patient presents with symptoms of deep vein thrombosis and is found to have a mutation in the gene encoding for antithrombin. Which of the following would be an appropriate initial treatment for this patient?

A Administration of recombinant Factor VIIa
B Infusion of fresh frozen plasma to replenish antithrombin levels
C Initiation of warfarin therapy to inhibit vitamin K-dependent clotting factors
D Use of low molecular weight heparin as an anticoagulant ✓

Explanation

Low molecular weight heparin is an appropriate initial treatment for deep vein thrombosis, especially in patients with antithrombin deficiency, as it does not rely on antithrombin for its anticoagulant effect.

Source

Clinical guidelines for the management of thrombosis and coagulation disorders
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium