Amrinone Drugs : Dose, Action, side effects and Contra-indications

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Amrinone is a positive inotropic agent and phosphodiesterase inhibitor used in the treatment of congestive Cardiac failure. Now a day Amrinone is not used because of toxicity effect; long term uses shown increase mortality. 

Dose of Amrinone Drugs

  1. Milrinone : 5 μg/kg IV bolus injection followed by 2-20 μg/kg/min infusion.
  2. Vesnarinone : 60 mg/day orally.

Action of Amrinone

  • Amrinone inhibits the enzyme phospho- diesterase which metabolises cyclic 3,5 AMP to the inactive cyclic 5 AMP. It’s causes vasodilatation with fall in systemic vascular resistance. It’s enhances influx of calcium ions through Ca-channels. It increases the force of contraction & velocity of relaxation of cardiac muscle.
  • It increases the level of a chemical messenger (cAMP), which helps the smooth muscles to relax. Amrinone is a vasodilator; thus, dilates the blood vessels to a better blood flow in to the heart.
  • It also promotes the heart’s contractile ability to pump more blood.

 Common side effects of Amrinone

Contra-indications of Amrinone

  • Patients with aortic Stenosis, 
  • Hypertrophic Cardiomyopathy,
  • History of hypersensitivity to the drug.

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