Which of the following types of anemia is characterized by an imbalance in the synthesis of alpha-globin and beta-globin chains, resulting in the accumulation of excess alpha-globin chains?

A Beta-thalassemia major
B Alpha-thalassemia major ✓
C Sickle cell anemia
D Hereditary spherocytosis

Explanation

Alpha-thalassemia major is a severe form of anemia caused by a deficiency in the production of alpha-globin chains, leading to an accumulation of excess beta-globin chains.

Source

Wintrobe's Clinical Hematology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high