Which of the following statements is true regarding the Kell blood group system?

A It is the most common cause of hemolytic disease of the newborn
B It is a high-prevalence antigen, found on nearly all red blood cells
C It is a low-prevalence antigen, found on fewer than 10% of red blood cells ✓
D It is not clinically significant in transfusion medicine

Explanation

The Kell blood group system is a low-prevalence antigen, found on fewer than 10% of red blood cells, but can still cause significant hemolysis if an individual with anti-Kell antibodies receives Kell-positive blood.

Source

AABB Technical Manual
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high