How does the cold agglutinin disease affect red blood cell survival?

A It causes red blood cells to agglutinate at temperatures below 37°C ✓
B It leads to red blood cell lysis due to complement activation
C It results in red blood cell sequestration in the spleen
D It has no significant impact on red blood cell survival

Explanation

Cold agglutinin disease is characterized by the production of autoantibodies that bind to red blood cells at temperatures below 37°C, leading to their agglutination.

Source

Clinical hematology textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: medium