Which of the following signaling pathways plays a crucial role in the regulation of hematopoietic stem cell migration and homing to the bone marrow niche?

A Wnt/β-catenin pathway
B PI3K/AKT pathway
C SDF-1/CXCR4 pathway ✓
D JAK/STAT pathway

Explanation

The SDF-1/CXCR4 pathway is critical for the migration and homing of hematopoietic stem cells to the bone marrow niche, guiding them to specific areas for lodging and self-renewal.

Source

Blood Journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high