Which of the following proteins plays a crucial role in the adhesion of hematopoietic stem cells to the bone marrow niche?

A Vascular cell adhesion molecule-1 (VCAM-1) ✓
B Intercellular adhesion molecule-1 (ICAM-1)
C Platelet endothelial cell adhesion molecule-1 (PECAM-1)
D Lymphocyte function-associated antigen 1 (LFA-1)

Explanation

Vascular cell adhesion molecule-1 (VCAM-1) plays a crucial role in the adhesion of hematopoietic stem cells to the bone marrow niche, facilitating their interaction with the stromal cells and maintaining their position within the niche.

Source

Blood Journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: medium