Which of the following nutrients plays a crucial role in the regulation of homocysteine metabolism, and its deficiency is associated with an increased risk of cardiovascular disease?

A Folate
B Vitamin B12
C Vitamin B6
D All of the above ✓

Explanation

Folate, vitamin B12, and vitamin B6 are all involved in the regulation of homocysteine metabolism, and deficiencies in these nutrients can increase the risk of cardiovascular disease.

Mnemonic

Folate, B12, B6 = Fab trio for heart health

Source

American Journal of Clinical Nutrition
Metabolic and Nutritional Disorders Nutritional Disorders Homocysteine Metabolism Hard MEDICAL Confidence: high