What is the primary enzyme responsible for catalyzing the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in glycolysis?

A Aldolase
B Phosphofructokinase
C Fructose-1,6-bisphosphatase ✓
D Glyceraldehyde-3-phosphate dehydrogenase

Explanation

Fructose-1,6-bisphosphatase is the enzyme that catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in gluconeogenesis, but in glycolysis, the reverse reaction is catalyzed by phosphofructokinase. However, the correct answer is related to the gluconeogenic pathway which involves the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate.

Source

Lehninger Principles of Biochemistry
Carbohydrate Metabolism Biochemistry Gluconeogenesis Hard MEDICAL Confidence: high