Which of the following is a key regulator of the biosynthesis of cholesterol?

A HMG-CoA synthase
B HMG-CoA reductase ✓
C Acetyl-CoA carboxylase
D Fatty acid synthase

Explanation

HMG-CoA reductase is the rate-limiting enzyme in the biosynthesis of cholesterol, and its activity is tightly regulated by feedback inhibition and other mechanisms.

Mnemonic

HMG = 'Hero' of cholesterol synthesis, Reductase = 'Reduce' the amount

Source

Biochemistry by Jeremy Berg
Lipid Metabolism Biochemistry Cholesterol Biosynthesis Hard MEDICAL Confidence: high