Which of the following enzymes is responsible for the conversion of pyrimidine nucleotides to purine nucleotides in hematopoietic cells?

A Ribonucleotide reductase
B Purine nucleoside phosphorylase
C Hypoxanthine-guanine phosphoribosyltransferase ✓
D Adenosine deaminase

Explanation

Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme that plays a crucial role in the purine salvage pathway, converting hypoxanthine and guanine to their respective monophosphate nucleotides, which can then be used for DNA synthesis in hematopoietic cells.

Source

Biochemistry textbook by Berg et al.
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high