What is the role of the Hedgehog signaling pathway in the development of hematopoietic stem cells?

A Regulation of self-renewal and proliferation ✓
B Induction of apoptosis and differentiation
C Maintenance of quiescence and dormancy
D Stimulation of angiogenesis and vascularization

Explanation

The Hedgehog signaling pathway plays a crucial role in the regulation of self-renewal and proliferation of hematopoietic stem cells, particularly during embryonic development.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high