Which of the following coagulation disorders is characterized by an increased risk of thrombosis due to an imbalance between procoagulant and anticoagulant factors, resulting from a gain-of-function mutation in the protein C or protein S gene?
Explanation
Factor V Leiden thrombophilia is a coagulation disorder characterized by an increased risk of thrombosis due to a gain-of-function mutation in the factor V gene, leading to an imbalance between procoagulant and anticoagulant factors.
Source
Hematology textbooks and research articles