What is the role of von Willebrand factor in hemostasis?

A It acts as a cofactor for factor VIII in the intrinsic pathway
B It helps to stabilize factor VIII in the circulation
C It mediates platelet adhesion to the damaged vascular endothelium ✓
D It inhibits the activation of protein C

Explanation

Von Willebrand factor plays a crucial role in mediating platelet adhesion to the damaged vascular endothelium, which is essential for the formation of a platelet plug during hemostasis.

Mnemonic

VWF = Von Willebrand Factor, 'v' for vessel wall

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high