Which of the following anemias is characterized by a mutation in the HBB gene, leading to a reduction in beta-globin chain production?

A Alpha-thalassemia
B Beta-thalassemia ✓
C Sickle cell anemia
D Hereditary spherocytosis

Explanation

Beta-thalassemia is caused by a mutation in the HBB gene, which codes for the beta-globin chain of hemoglobin. This leads to a reduction in beta-globin chain production and results in anemia.

Source

National Heart, Lung, and Blood Institute
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high