Which blood group antigen is known for being highly immunogenic and can cause severe hemolytic disease of the fetus and newborn when an RhD-negative mother is sensitized to RhD-positive blood?

A K1 antigen of the Kell blood group system
B Fy(a) antigen of the Duffy blood group system
C RhD antigen of the Rh blood group system ✓
D Jk(a) antigen of the Kidd blood group system

Explanation

The RhD antigen of the Rh blood group system is highly immunogenic and can cause severe hemolytic disease of the fetus and newborn (HDFN) when an RhD-negative mother is sensitized to RhD-positive blood, typically during a first pregnancy or through transfusion of RhD-positive blood components.

Source

Hematology and Transfusion Medicine literature
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high