Which blood group antigen is associated with an increased risk of hemolytic disease of the newborn due to its high immunogenicity?

A RhD ✓
B Kell
C Duffy
D MNS

Explanation

The RhD antigen is highly immunogenic and can cause hemolytic disease of the newborn if an RhD-negative mother is sensitized to RhD-positive blood.

Source

Williams Hematology
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high