What is the significance of the Ii blood group system in relation to cold agglutinin disease?

A It is associated with an increased risk of hemolytic transfusion reactions
B It is related to the production of cold agglutinins, which can cause red blood cell agglutination at cold temperatures ✓
C It is a rare blood group system with no clinical significance
D It is associated with an increased risk of bleeding disorders

Explanation

The Ii blood group system is related to the production of cold agglutinins, which can cause red blood cell agglutination at cold temperatures, leading to cold agglutinin disease.

Source

American Association of Blood Banks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high