What is the significance of the endothelial niche in hematopoiesis?
A
It provides a site for hematopoietic stem cell proliferation
B
It regulates the homing of hematopoietic stem cells to the bone marrow
C
It produces cytokines that support the differentiation of hematopoietic progenitor cells
D
It maintains the quiescence of hematopoietic stem cells
✓
Explanation
The endothelial niche plays a crucial role in maintaining the quiescence of hematopoietic stem cells, which is essential for their long-term self-renewal and multilineage potential.
Source
Nature Reviews Immunology
Hematology
Hematology: Hematopoiesis
Hematology: Hematopoiesis
Hard
MEDICAL
Confidence: high
