What is the purpose of using a two-stage crossmatch procedure in blood banking?

A To detect ABO incompatibility
B To detect Rh incompatibility
C To detect non-ABO antibodies and prevent hemolytic transfusion reactions ✓
D To detect bacterial contamination in blood products

Explanation

The two-stage crossmatch procedure is used to detect non-ABO antibodies, which can cause hemolytic transfusion reactions, and to prevent these reactions by identifying incompatible blood products.

Source

Blood Banking Guidelines
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Easy MEDICAL Confidence: high