What is the primary mechanism by which the ABO blood group antigens are synthesized and expressed on red blood cells?

A Glycosylation of proteins
B Phosphorylation of lipids
C Fatty acid synthesis
D N-glycan biosynthesis ✓

Explanation

The ABO blood group antigens are synthesized and expressed on red blood cells through the process of N-glycan biosynthesis, where specific enzymes add carbohydrate molecules to protein or lipid backbones.

Source

Lecture Notes in Biochemistry
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high