What is the primary mechanism by which hepcidin regulates iron homeostasis in the body, leading to anemia in cases of dysregulation?

A By increasing the absorption of iron from the gut
B By decreasing the release of iron from macrophages
C By binding to ferroportin and inducing its degradation ✓
D By stimulating the production of erythropoietin

Explanation

Hepcidin plays a crucial role in regulating iron metabolism by binding to ferroportin, the only known iron exporter, and inducing its degradation. This leads to a decrease in iron export from cells and a reduction in plasma iron levels, potentially causing anemia if hepcidin levels are inappropriately elevated.

Source

Recent research articles on hepcidin and iron metabolism
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high