A patient presents with anemia and is found to have a high level of adenosine deaminase (ADA) enzyme activity. Which of the following conditions is most likely associated with this finding?

A Hereditary spherocytosis
B Glucose-6-phosphate dehydrogenase (G6PD) deficiency
C Pyruvate kinase deficiency
D Severe combined immunodeficiency disease (SCID) ✓

Explanation

Elevated adenosine deaminase (ADA) activity is particularly associated with severe combined immunodeficiency disease (SCID), a condition that affects the immune system and can lead to various complications including anemia due to impaired lymphocyte development and function.

Source

Clinical immunology and hematology textbooks
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high