What is the primary mechanism by which hematopoietic stem cells maintain their quiescence and prevent excessive proliferation?

A Cell cycle arrest ✓
B Apoptosis
C Differentiation
D Senescence

Explanation

Hematopoietic stem cells maintain their quiescence primarily through cell cycle arrest, which prevents them from excessively proliferating and helps preserve their self-renewal capacity.

Source

Blood Journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high