What is the primary mechanism by which activated protein C regulates coagulation?

A Inhibition of factor VIIIa ✓
B Activation of factor XII
C Inhibition of thrombin formation
D Stimulation of fibrinolysis

Explanation

Activated protein C regulates coagulation by inhibiting factor VIIIa, which is a critical component of the tenase complex.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high