What is the primary enzyme responsible for the conversion of phenylalanine to tyrosine in the human body, and its deficiency leads to phenylketonuria (PKU)?

A Phenylalanine hydroxylase ✓
B Tyrosinase
C Tryptophan hydroxylase
D Homogentisate oxidase

Explanation

Phenylalanine hydroxylase is the enzyme responsible for converting phenylalanine to tyrosine, and its deficiency leads to the accumulation of phenylalanine, causing PKU.

Mnemonic

PKU = PhenylKeeps Underground → phenylalanine hydroxylase keeps phenylalanine under control

Source

NCERT Class 12 Biochemistry
Enzymes in Disease Biochemistry Amino Acid Metabolism Disorders Hard MEDICAL Confidence: high