How does the enzyme dihydroorotate dehydrogenase contribute to the development of rheumatoid arthritis?

A Inhibition of pyrimidine synthesis
B Stimulation of purine synthesis
C Enhancement of lymphocyte proliferation ✓
D Production of pro-inflammatory cytokines

Explanation

Dihydroorotate dehydrogenase is involved in pyrimidine synthesis. Inhibitors of this enzyme have been shown to suppress lymphocyte proliferation, which is elevated in rheumatoid arthritis.

Source

Journal of Immunology
Enzymes in Disease Immunology Autoimmune Diseases Medium MEDICAL Confidence: medium