A patient with anemia is found to have a high level of erythrocyte-bound immunoglobulin, what is the most likely diagnosis?

A Autoimmune hemolytic anemia (AIHA) ✓
B Hereditary spherocytosis
C Paroxysmal nocturnal hemoglobinuria (PNH)
D Anisocytosis

Explanation

The presence of erythrocyte-bound immunoglobulin is a hallmark of autoimmune hemolytic anemia (AIHA), where the immune system produces antibodies against the patient's own red blood cells, leading to their destruction.

Mnemonic

_AIHA = Auto-Immune 'Hit' Against Hemoglobin

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high