A patient presents with anemia and is found to have a high level of hemoglobin F. What is the most likely diagnosis?

A Beta-thalassemia major
B Hereditary persistence of fetal hemoglobin ✓
C Sickle cell disease
D Alpha-thalassemia

Explanation

Hereditary persistence of fetal hemoglobin (HPFH) is a rare condition where high levels of fetal hemoglobin (HbF) persist into adulthood, often presenting with anemia or being asymptomatic.

Source

Wintrobe's Clinical Hematology
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high