What is the significance of using LISS (Low Ionic Strength Solution) in hemagglutination reactions during blood grouping?

A To enhance the reactivity of IgM antibodies ✓
B To reduce the reactivity of IgG antibodies
C To improve the visibility of agglutination reactions
D To inhibit the complement system

Explanation

LISS is used to enhance the reactivity of IgM antibodies, which are responsible for ABO blood group reactions, by reducing the ionic strength of the solution and allowing for better interaction between antibodies and antigens.

Mnemonic

LISS = Little Ionic Strength Solution → helps little IgM antibodies react

Source

Technical Manual of the American Association of Blood Banks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high