Which of the following blood group antigens is associated with a higher risk of hemolytic disease of the fetus and newborn (HDFN)?

A RhD antigen
B Kell antigen ✓
C Duffy antigen
D MNS antigen

Explanation

The Kell antigen is associated with a higher risk of HDFN due to its high immunogenicity and the potential for severe hemolysis.

Mnemonic

Kell = Key to understanding HDFN → Kell antigen is a key player

Source

Williams Hematology, 9th edition
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: medium