What is the primary mechanism by which anti-A and anti-B antibodies cause hemolysis in ABO-incompatible blood transfusions?

A Complement-mediated lysis ✓
B Antibody-dependent cellular cytotoxicity
C Activation of the coagulation cascade
D Release of inflammatory cytokines

Explanation

The primary mechanism by which anti-A and anti-B antibodies cause hemolysis in ABO-incompatible blood transfusions is through complement-mediated lysis, where the binding of these antibodies to their respective antigens on red blood cells activates the complement system, leading to cell lysis.

Source

Transfusion Medicine textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high