Which of the following blood group systems is associated with a higher risk of hemolytic disease of the fetus and newborn (HDFN)?

A Rh blood group system ✓
B Kell blood group system
C Duffy blood group system
D MNS blood group system

Explanation

The Rh blood group system is associated with a higher risk of HDFN due to the potential for Rh incompatibility between the mother and fetus, which can lead to hemolysis of fetal red blood cells.

Source

National Institute of Child Health and Human Development (NICHD) guidelines
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high