What is the difference between the Kell and Duffy blood group systems in terms of their clinical significance in hemolytic disease of the newborn?

A Kell system is more significant due to its higher frequency of alloantibodies ✓
B Duffy system is more significant due to its stronger antigen expression
C Both systems have equal clinical significance in HDN
D Kell system is less significant due to its lower frequency of alloantibodies

Explanation

The Kell blood group system is more clinically significant in hemolytic disease of the newborn (HDN) due to the higher frequency of alloantibodies against Kell antigens, particularly anti-K1.

Source

Transfusion Medicine textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high