How does the use of low-ionic-strength saline (LISS) affect the performance of indirect antiglobulin tests in blood banking?

A It decreases the sensitivity of the test by reducing antibody binding
B It increases the sensitivity of the test by enhancing antibody binding ✓
C It has no effect on the sensitivity of the test
D It reduces the specificity of the test by increasing non-specific binding

Explanation

The use of low-ionic-strength saline (LISS) in indirect antiglobulin tests enhances antibody binding, thereby increasing the sensitivity of the test for detecting alloantibodies.

Source

Immunohematology laboratory manuals
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: medium