What is the purpose of using low-ionic-strength solution (LISS) in indirect antiglobulin testing?

A To enhance the reactivity of IgM antibodies
B To reduce the reactivity of IgG antibodies
C To increase the sensitivity of the test for detecting weak antibodies ✓
D To decrease the risk of hemolysis during crossmatching

Explanation

Low-ionic-strength solution (LISS) is used to increase the sensitivity of indirect antiglobulin testing by enhancing the reaction between antibodies and red blood cells.

Source

Technical Manual of the American Association of Blood Banks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high