A patient with a history of recurrent venous thromboembolism is found to have a mutation in the MTHFR gene. What is the most likely underlying coagulation disorder?

A Protein C deficiency
B Protein S deficiency
C Antithrombin deficiency
D Homocystinuria ✓

Explanation

A mutation in the MTHFR gene can lead to elevated homocysteine levels, resulting in homocystinuria, which is a risk factor for venous thromboembolism.

Source

Genetics and hematology research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium