What is the primary mechanism by which activated protein C exerts its anticoagulant effect?

A Inhibition of factor Xa
B Inactivation of factors Va and VIIIa ✓
C Stimulation of fibrinolysis
D Enhancement of thrombin generation

Explanation

Activated protein C exerts its anticoagulant effect primarily by inactivating factors Va and VIIIa, which are essential for the coagulation cascade.

Source

Hematology textbooks and research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high