What is the primary mechanism by which heparin induces osteoporosis in patients with coagulation disorders?

A Inhibition of osteoblast activity
B Stimulation of osteoclast activity ✓
C Increased excretion of calcium in the urine
D Decreased absorption of calcium from the gut

Explanation

Heparin can induce osteoporosis by stimulating osteoclast activity, leading to increased bone resorption and decreased bone density.

Source

New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium