What is the significance of lupus anticoagulant in the diagnosis of antiphospholipid syndrome?

A It is a procoagulant antibody that increases the risk of thrombosis ✓
B It is an anticoagulant antibody that decreases the risk of thrombosis
C It is a marker of autoimmune disorders, but not directly related to coagulation
D It is a diagnostic marker for systemic lupus erythematosus

Explanation

Lupus anticoagulant is an autoantibody that increases the risk of thrombosis, despite its name suggesting an anticoagulant effect. It is a key diagnostic marker for antiphospholipid syndrome.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high