What is the primary mechanism by which heparin induces osteoporosis in patients on long-term therapy?

A Inhibition of osteoblast function and promotion of osteoclast activity ✓
B Stimulation of osteoblast function and inhibition of osteoclast activity
C Increased excretion of calcium in the urine
D Decreased absorption of calcium from the gut

Explanation

Heparin can induce osteoporosis by inhibiting osteoblast function and promoting osteoclast activity, leading to an imbalance in bone remodeling.

Source

Williams Hematology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium