What is the significance of the lupus anticoagulant in the diagnosis of antiphospholipid syndrome?
A
It is a procoagulant antibody that increases the risk of thrombosis
✓
B
It is an anticoagulant antibody that decreases the risk of thrombosis
C
It is a marker of autoimmune disorders, but not directly related to coagulation
D
It is a diagnostic marker for systemic lupus erythematosus, but not specific to antiphospholipid syndrome
Explanation
The lupus anticoagulant is an antibody that increases the risk of thrombosis in patients with antiphospholipid syndrome, despite its name suggesting an anticoagulant effect.
Mnemonic
Lupus = Loop → loops back to increase thrombosis risk
Source
Harrison's Principles of Internal Medicine
Hematology
Hematology: Coagulation Disorders
Hematology: Coagulation Disorders
Medium
MEDICAL
Confidence: high
