What is the role of plasminogen activator inhibitor-1 (PAI-1) in the fibrinolytic pathway?

A It activates plasminogen to form plasmin
B It inhibits the activity of tissue plasminogen activator (tPA) ✓
C It breaks down fibrin clots into soluble degradation products
D It regulates the expression of genes involved in coagulation and fibrinolysis

Explanation

PAI-1 is a protein that inhibits the activity of tPA, which is responsible for activating plasminogen to form plasmin. Plasmin then breaks down fibrin clots into soluble degradation products.

Source

Biochemistry and molecular biology textbooks and research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high