What is the significance of the FV Leiden mutation in the development of thrombophilia?

A It leads to an increase in antithrombin III levels
B It results in a deficiency of protein C
C It causes a mutation in the factor V gene, leading to resistance to activated protein C ✓
D It is associated with an increased risk of bleeding disorders

Explanation

The FV Leiden mutation is a genetic variant that leads to a mutation in the factor V gene, resulting in resistance to activated protein C and an increased risk of thrombophilia.

Source

Hematology textbooks and research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high