A patient with a coagulation disorder is found to have a deficiency of plasminogen activator inhibitor-1 (PAI-1). What would be the expected outcome?

A Increased risk of thrombosis
B Decreased risk of thrombosis
C Increased risk of bleeding ✓
D Decreased risk of bleeding

Explanation

PAI-1 inhibits the activity of plasminogen activators, which are responsible for activating plasmin and breaking down blood clots. A deficiency of PAI-1 would lead to increased fibrinolysis and an increased risk of bleeding.

Mnemonic

PAI-1 = Prevents Activation, Increases 1 (clot)

Source

Hematology: Clinical Principles and Applications
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium