A patient with a history of recurrent venous thromboembolism is found to have a mutation in the gene encoding which protein, leading to an increased risk of thrombosis?

A Protein S
B Protein C
C Antithrombin III
D Factor V Leiden ✓

Explanation

The Factor V Leiden mutation is a common cause of inherited thrombophilia, leading to an increased risk of recurrent venous thromboembolism.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high