What is the mechanism by which activated protein C exerts its anticoagulant effect in the coagulation cascade?

A Inhibition of factor Va and factor VIIIa ✓
B Activation of factor XII and factor XI
C Enhancement of thrombin generation
D Inhibition of platelet aggregation

Explanation

Activated protein C exerts its anticoagulant effect by inhibiting the activity of factor Va and factor VIIIa, which are essential for the generation of thrombin.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high